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Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin

de Franciscis, V.; Rosati, R.; Colucci-D'Amato, G.L.; Eva, A.; Vecchio, G.

Cancer Research 51(16): 4234-4237

1991

ISSN/ISBN: 0008-5472
PMID: 1868443
Document Number: 383717
We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.

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