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Enhancement of rat liver mitochondrial function by portal branch ligation secures subsequent extended hepatectomy

Katoh, T.; Tanaka, M.; Nimura, Y.; Kanai, M.; Nagino, M.; Ozawa, T.

Biochemistry International 24(1): 107-116

1991

ISSN/ISBN: 0158-5231
PMID: 1768249
Document Number: 382944
We have examined the effects of portal branch ligation on liver mitochondrial function and on subsequent extended hepatectomy in rat. In the occluded lobes, mitochondrial function was depressed immediately after the ligation. In the unoccluded lobes, mitochondrial function was enchanced and reached the maximum two days after the ligation. This enhancement was associated with increases in the enzymic activities and subunit amounts of the energy-transducing complexes, and with increase in mitochondrial DNA content. The ligation improved both survival rate and mitochondrial redox state monitored by the ratio of acetoacetate to .beta.-hydroxybutyrate after hepatectomy. These results suggest that the enhancement of mitochondrial function by portal branch ligation fills the energy demand for liver regeneration.

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