Response to the administration of corticosteroids in patients with chronic obstructive lung disease and asthma
Barbas Filho, J.V.; Barbas, C.S.; de Carvalho, C.R.; Godoy, R.; Vianna, E.dos.S.; Lorenzi Filho, G.
Revista do Hospital das Clinicas 46(4): 159-162
1991
ISSN/ISBN: 0041-8781 PMID: 1843711 Document Number: 380586
A spirometric study was performed in order to evaluate the response to the administration of 200 mg of salbutamol, just before and after the daily administration of 8 mg of triamcinolone, for an average period of 2 weeks, in 21 patients with chronic obstructive pulmonary disease or asthma. Eleven patients responded with a significant increase of FVC or FEV1 or FEF25-75%, after administration of corticoid. Ten patients did not respond. In average there was a significant increase of the FVC and VEF1 (p < 0.01) and of FEF25-75% (p < 0.05) after the administration of corticoid. There was no significant difference between the responders and not responders when the age, initial FVC, FEV1 and FEF25-75% were taken in consideration. A significantly greater number of responders to corticoid responded also to the bronchodilator with an increase of FEF25-75%. There was a significant negative correlation between the intensity of the response to corticoid versus bronchodilator measured with delta FEF25-75%. The administration of corticoid did not change the response to bronchodilator.