Some parameters of endocrine function in patients with hemophilia
Dedov, I.I.; Germanov, V.A.; Zakharova, N.O.
Problemy Endokrinologii 37(6): 38-41
1991
ISSN/ISBN: 0375-9660 PMID: 1664953 Document Number: 380201
The hormonal status of 40 patients with hemophilia A and in 5 patients with hemophilia B was investigated by radioimmunoassay during exacerbation against a background of the hemorrhagic syndrome and in remission. A decrease in the plasma levels of cortisol, T3, insulin and high levels of ACTH and estradiol were observed in patients with a severe type hemophilia during exacerbation. Remission was characterized by an increase in the STH level and a decrease in the ACTH level. The severity of hemorrhagic manifestations was determined not only by a degree of a decrease in the level of blood factor VIII but also by a degree of a decrease in the levels of cortisol, T3 and insulin. Hormonal drugs (prednisolone, thyroidin and methyl androstenediol) were also included in multimodality therapy of hemophilia.