Animal experimental and human pharmacologic studies with phase-Ii metabolites of triamterene
Völger, K.D.
Arzneimittel-Forschung 41(5): 499-506
1991
ISSN/ISBN: 0004-4172 PMID: 1898420 Document Number: 379412
Animal Experiments and Human Studies with the Phase-II Metabolite of Triamterene The described animal experiments as well as the pharmacological investigations in man show the diuretic efficacy of the phase-II metabolite of triamterene (CAS 396-01-0), OH-TA-ester. As demonstrated in the present investigation, a phase-II metabolite can not be considered only as an ineffective conjugation product, formed to accomplish the excretion of a foreign compound, but also it must be considered as an important factor in the therapy, if its pharmacologic efficacy has been established, moreover if as a result of disease-related alterations in the pharmacokinetics the phase-II metabolite cumulates.