The terminal complement complex (TCC) --a mediator in the development of disease in man?
Garred, P.
Ugeskrift for Laeger 153(5): 351-353
1991
ISSN/ISBN: 0041-5782 PMID: 1994560 Document Number: 379197
Activation of the terminal complement pathway leads to the formation of the terminal complement complexes (TCC). TCC exists in one active membrane form, C5b-9 and in one inactive fluid phase form, SC5b-9. The paper explores the structure and regulatory mechanisms of TCC. In addition, methods of detecting TCC in tissue and in biological fluids, guidelines for sampling and the importance of TCC as an inflammatory mediator in human disease are discussed.
Document emailed within 1 workday
Related Documents
Byers, P.H.; Ward, P.A.; Kellermeyer, R.W.; Naff, G.B. 1973: Complement as a mediator of inflammation in acute gouty arthritis. II. Biological activities generated from complement by the interaction of serum complement and sodium urate crystals Journal of Laboratory and Clinical Medicine 81(5): 761-769Rus, H.G.; Niculescu, F.; Nanulescu, M.; Cristea, A.; Florescu, P. 1986: Immunohistochemical detection of the terminal C5b-9 complement complex in children with glomerular diseases Clinical and Experimental Immunology 65(1): 66-72
Schäfer, H.; Mathey, D.; Hugo, F.; Bhakdi, S. 1986: Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium Journal of Immunology 137(6): 1945-1949
Niculescu, F.; Hugo, F.; Rus, H.G.; Vlaicu, R.; Bhakdi, S. 1987: Quantitative evaluation of the terminal C5b-9 complement complex by ELISA in human atherosclerotic arteries Clinical and Experimental Immunology 69(2): 477-483
Halstensen, T.S.; Mollnes, T.E.; Garred, P.; Brandtzaeg, P. 1988: Deposits of terminal complement complex and S-protein on follicular dendritic cells in human lymphoid tissue Advances in Experimental Medicine and Biology 237: 185-189
Shirazi, Y.; McMorris, F.A.; Shin, M.L. 1989: Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids Journal of Immunology 142(12): 4385-4391
Liu, Z.Y.; Sanders, M.E.; Hu, V.W. 1989: Effect of complement on the lateral mobility of erythrocyte membrane proteins. Evidence for terminal complex interaction with cytoskeletal components Journal of Immunology 142(7): 2370-2376
Corvetta, A.; Pomponio, G.; Rinaldi, N.; Luchetti, M.M.; Di Loreto, C.; Stramazzotti, D. 1992: Terminal complement complex in synovial tissue from patients affected by rheumatoid arthritis, osteoarthritis and acute joint trauma Clinical and Experimental Rheumatology 10(5): 433-438
Triolo, G.; Giardina, E.; Casiglia, D.; Scarantino, G.; Bompiani, G.D. 1991: Detection of the terminal fluid-phase complement complex, SC5b-9, in the plasma of patients with insulin-dependent (type I) diabetes mellitus. Relation to increased urinary albumin excretion and plasma von Willebrand factor Clinical and Experimental Immunology 84(1): 53-58
Hara, M.; Batsford, S.R.; Mihatsch, M.J.; Bitter-Suermann, D.; Vogt, A. 1991: Complement and monocytes are essential for provoking glomerular injury in passive Heymann nephritis in rats. Terminal complement components are not the sole mediators of proteinuria Laboratory Investigation; a Journal of Technical Methods and Pathology 65(2): 168-179
Müller-Peddinghaus, R. 1983: The complement system as a mediator of acute inflammation Deutsche Tierärztliche Wochenschrift 90(9): 374-377
Weetman, A.P.; Cohen, S.B.; Oleesky, D.A.; Morgan, B.P. 1989: Terminal complement complexes and C1/C1 inhibitor complexes in autoimmune thyroid disease Clinical and Experimental Immunology 77(1): 25-30
Sundsmo, J.S.; Curd, J.G.; Kolb, W.P.; Müller-Eberhard, H.J. 1978: Leukocyte complement: assembly of the membrane attack complex of complement by human peripheral blood leukocytes in the presence and absence of serum Journal of Immunology 120(3): 855-860
Dias da Silva, W.; Kipnis, T.L. 1984: Complement system: an ingenious biochemical mechanism, a co-participant in the natural defense and a mediator of cell interaction Amb: Revista da Associacao Medica Brasileira 30(3-4): 67-72
Nishioka, K. 1970: Complement and immune complex. Molecular anatomy and function of C3 molecule on antigen-antibody complex Folia Allergologica 17(4): 427
Kochi, S.K.; Johnson, R.C.; Dalmasso, A.P. 1991: Complement-mediated killing of the Lyme disease spirochete Borrelia burgdorferi. Role of antibody in formation of an effective membrane attack complex Journal of Immunology 146(11): 3964-3970
Solomkin, J.S.; Cotta, L.A.; Satoh, P.S.; Hurst, J.M.; Nelson, R.D. 1985: Complement activation and clearance in acute illness and injury: evidence for C5a as a cell-directed mediator of the adult respiratory distress syndrome in man Surgery 97(6): 668-678
Rodríguez-Membrilla, A.; Martínez, V.; Jiménez, M.; Goñalons, E.; Vergara, P. 1995: Is nitric oxide the final mediator regulating the migrating myoelectric complex cycle? American Journal of Physiology 268(2 Pt 1): G207-G214
Preissner, K.T.; Podack, E.R.; Müller-Eberhard, H.J. 1985: The membrane attack complex of complement: relation of C7 to the metastable membrane binding site of the intermediate complex C5b-7 Journal of Immunology 135(1): 445-451
Brandeis, W.E.; Tan, C.; Wang, Y.; Good, R.A.; Day, N.K. 1980: Circulating immune complexes, complement and complement component levels in childhood Hodgkin's disease Clinical and Experimental Immunology 39(3): 551-561