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Primary biliary cirrhosis and pregnancy. Apropos of a clinical case. Review of the literature

Marpeau, L.; Benifla, J.L.; Chazoullière, O.; Larue, L.; Pigné, A.; Poupon, R.; Barrat, J.

Journal de Gynecologie Obstetrique et Biologie de la Reproduction 20(6): 805-807

1991

ISSN/ISBN: 0368-2315
PMID: 1822489
Document Number: 379032
The appearance of pruritus and abnormal liver function tests (cellular damage) during pregnancy should of course suggest the diagnosis of intrahepatic cholestasis of pregnancy. However, these signs must also be recognized as signs of other hepatic diseases, especially primary biliary cirrhosis. The diagnosis is based on the search for antimitochondrial antibodies. This mode of presentation must not be overlooked because of major therapeutic consequences. The disease course often stabilizes with ursodeoxycholic acid, if administrated early.

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