An economic evaluation in the pharmacokinetic prediction of preventive carbamazepine therapy
Ushakov, I.V.; Kostiukova, E.G.; Kudriakova, T.B.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 91(3): 94-96
1991
ISSN/ISBN: 0044-4588 PMID: 1646552 Document Number: 378976
The paper is concerned with the data of economic evaluation of pharmacokinetic prediction of the individual efficacy of preventive carbamazepin therapy of patients suffering from affective and schizoaffective psychoses. The study was carried out with the aid of the indicators of "direct" and "indirect" expenditures characterizing the efficacy of the use of carbamazepin in the treatment period as compared to the control one, using the pharmacokinetic predictors of the efficacy and without them. The potential economic efficacy of carbamazepin therapy appreciably increases provided the differential diagnostic indications for drug administration are specified. Such a technique of economic analysis of the data of psychopharmacokinetic studies enables their quantitative estimation and determination of economically important research priorities in that area.