Expression of CD56 antigen on acute nonlymphocytic leukemia
Yamane, T.; Inoue, T.; Furukawa, Y.; Yasui, Y.; Ota, K.; Nakao, Y.; Ohira, H.; Tanaka, K.; Hasuike, T.; Hirai, M.
Rinsho Byori. Japanese Journal of Clinical Pathology 39(12): 1347-1350
1991
ISSN/ISBN: 0047-1860 PMID: 1723434 Document Number: 378278
CD56 antigen (detected by NKH-1) is distributed on NK cells, monocytes, and ectodermal neural cells. In this study, the blasts of 29.2% of 27 patients with acute nonlymphocytic leukemia (ANLL) expressed CD56 antigen, but not CD16, CD2, or CD3 antigen. Leukemic cells isolated from 3 patients with CD56-positive ANLL did not have NK activity. There were no significant differences between CD56-positive and CD56-negative ANLL in CD13-positive cases, CD33-positive cases, and HLA-DR-positive cases. These results suggest that CD56-positive ANLL could be so-called mixed-lineage leukemia (lymphoid-associated antigen in ANLL).