Hypomelanosis of Ito: involvement of chromosome aberrations in this syndrome
Lenzini, E.; Bertoli, P.; Artifoni, L.; Battistella, P.A.; Baccichetti, C.; Peserico, A.
Annales de Genetique 34(1): 30-32
1991
ISSN/ISBN: 0003-3995 PMID: 1952789 Document Number: 378267
The authors report on cytogenetic results of six patients with hypomelanosis of Ito. Karyotypes from peripheral lymphocytes prometaphases and skin fibroblasts metaphases were normal. A review of the literature revealed no specific chromosomal abnormality but a close association between mosaicism and HI syndrome. The X-chromosome was involved in 53% of the abnormal cases.