Dose calibration of aztreonam in pediatric patients by means of pharmacokinetic analysis
Kawasaki, H.
Japanese Journal of Antibiotics 44(6): 635-642
1991
ISSN/ISBN: 0368-2781 PMID: 1890722 Document Number: 378127
One of the current pharmacological problems with antibiotics is possible overdose among children of 7 years of age and older, when their dose was calculated on a per kg basis. In order to evaluate the difficulties, a pharmacokinetic analysis of aztreonam (AZT), which is a monocyclic beta-lactam antimicrobial agent, was undertaken in 2 groups consisting of 5 children of ages 1 .apprx. 6 and older children of 7 .apprx. 15. Data from the younger children were fitted both to one- and two-compartment models while those from the older age group perfectly were fitted to a two-compartment model. Using these fitted curve, a simulation dose study was carried out in order to see if we can find a clue for a better dose calibration for the older group of children. The results suggest that the dose of AZT per kg basis for the older children can be reduced to 60% levels of the younger, that is, 60 mg/kg for the older in contrast to 100 mg/kg for the younger.