Hemoglobin phenotype of native residents in Tibet and structural analysis of HbE
Zheng, Y.
Zhonghua Yi Xue Za Zhi 71(12): 690
1991
ISSN/ISBN: 0376-2491 PMID: 1667373 Document Number: 378046
In this paper, the hemoglobin phenotype of 3,711 cases of native residents (Tibetan, 3,451 cases; Menba, 148 cases and LuoBa ethnic group, 122 cases) and 478 cases of immigrants. (totalling 4,190 cases), in 3 different sea-levels of the Autonomous Region of Tibet (Naqu-Ando, Lhasa-Rikeze and Lingzhi districts), are described. 11 cases (1 case in Tibetan, 6 cases in MenBa and 4 cases in LuoBa ethnic group) of slow-moving abnormal Hb were found. The mean incidence of abnormal Hb in the native residents was 2.98/1000. The incidence in MenBa and LuoBa ethical groups was remarkably higher than that in Tibetan. Besides, the Hb phenotypes of native residents were HbA, HbA2 and HbF. Structural analysis of the abnormal Hb by micro-crystal cellulose membrane and high performance liquid chromatography (HPLC) demonstrated that all the 11 cases of Hb variant in the native residents are HbE [ beta 26 (B8) Glu----Lys]. The distribution and characteristics of the abnormal Hb in Tibet are discussed.