Effect of captopril on pulmonary function
Ayache, A.S.; Salman, V.; Traub, Y.M.
Harefuah 120(4): 190-193
1991
ISSN/ISBN: 0017-7768 PMID: 2066020 Document Number: 377063
During the past few years, dry cough has been described as a possible adverse effect of treatment with angiotensin converting enzyme (ACE) inhibitors. There have been several studies of the effect of long-term administration of ACE inhibitors on pulmonary function. We examined spirometrically the effect of a single oral dose of captopril (25mg) on bronchial tonus in those who had not received the drug previously, in 4 patients who had previously had dry cough during ACE inhibitor therapy, in 20 patients with obstructive pulmonary disease and in 20 control subjects without pulmonary disease. 1 hour after ingestion of captopril there were no significant changes in the spirometric tests of any group. These findings supplement the results of similar tests done during long-term administration of ACE inhibitors, indicating that the pathogenesis of cough elicited by ACE inhibitor therapy does not seem to have an asthmatic basis.