Familial hypotrichosis of the scalp. Autosomal dominant inheritance in four generations

Ibsen, H.H.; Clemmensen, O.J.; Brandrup, F.

Acta Dermato-Venereologica 71(4): 349-351

1991


ISSN/ISBN: 0001-5555
PMID: 1681656
Document Number: 376721
We describe a Danish family of four generations suffering from hypotrichosis of the scalp. Age at onset was 6-17 years and almost total scalp alopecia was reached by the age of 14-21 years. No associated ectodermal defects were present. Nine of 22 persons covering four generations were affected. Growth of the scalp hair slowly decreased and was accompanied by a gradual, diffuse hair loss without regional variation. A scalp biopsy was performed, revealing a non-scarring alopecia with features of androgenetic alopecia. The pedigree was compatible with autosomal dominant inheritance.

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