The influence of different volatile inhaled anesthetics on the plasma protein binding of lidocaine
Kameue, T.
Masui. Japanese Journal of Anesthesiology 40(3): 421-430
1991
ISSN/ISBN: 0021-4892 PMID: 2072495 Document Number: 376489
The author investigated the interactions of protein binding of lidocaine by inhaled anesthetics (halothane, enflurane, isoflurane and sevoflurane) in vitro and in vivo. In in vitro, study, no significant changes of protein binding ratio were observed between the controls and any concentrations of the inhaled anesthetics even under high concentration (10 MAC). However, the percent of protein binding was inversely related to the total plasma lidocaine concentration. At lidocaine concentrations of 2, 5, and 9 .mu.g .cntdot. ml-1, the binding ratios were 66.37 .+-. 5.36 (%), 55.58 .+-. 4.38 (%) and 51.66 .+-. 4.12(%) respectively. By regression analysis (in vivo), the following relationship was obtained. Y = -066X .+-. 57.4 (Y:% of protein binding fraction, X: lidocaine concentration). In terms of lidocaine protein binding, there seems to be no hazard in using lidocaine with any inhaled anesthetics.