Activation of hyaluronidase by 8-methoxypsoralen-polyamine photoproducts
Shigehara, N.; Kakegawa, H.; Miyataka, H.; Matsumoto, H.; Isobe, A.; Satoh, T.
Photodermatology Photoimmunology and Photomedicine 8(6): 229-231
1991
ISSN/ISBN: 0905-4383 PMID: 1823146 Document Number: 376064
Ultraviolet radiation of 8-methoxypsoralen (8-MOP) in the presence of various polyamines resulted in stable photoproducts that were very soluble in water and showed hyaluronidase-activating properties. Among them, the photoproducts obtained from the reaction systems of 8-MOP-spermine and 8-MOP-spermidine markedly activated hyaluronidase. The enzyme activity was not affected by 8-MOP alone and the photoproduct of 8-MOP (8-MOP-P). From these facts, it was suggested that the photoproducts with hyaluronidase-activating properties might play an important role in the onset of 8-MOP-induced photosensitivity.