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Side effects of nifedipine in healthy probands within the scope of a discontinued bioavailability study

Meyer, F.P.; Banditt, P.; Walther, H.

Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 46(4): 110-113

1991

ISSN/ISBN: 0044-2542
PMID: 2058214
Document Number: 376055
In a prematurely discontinued bioavailability study of 40 mg nifidepine retard dragees, it was shown in four subjects that cardiovascular side effects may occur at nifedipine levels equal to or higher than some 80 ng/ml serum. These cases were suggestive of a relationship between the areas under the concentration vs. time curves in the range of side effects, AUC (tC80), and the so-called side effects scores which were derived from the number and the duration of undesirable side effects.

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