Prenatal DNA-diagnosis of Duchenne muscular dystrophy
Evgrafov, O.V.; Poliakov, A.V.; Zaĭtseva, S.P.; Vinogradov, S.V.; Bakharev, V.A.; Mil'man, F.A.; Lisova, L.P.; Zaretskaia, N.V.; Malygina, N.A.; Badalian, L.O.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 2: 15-16
1991
ISSN/ISBN: 0208-0613 PMID: 1674355 Document Number: 375911
Two prenatal diagnoses were carried out by the technique of intragenic polymorphous marker detecting heterozygosity in pregnant women in the families with cases of Duchenne muscular dystrophy. In both cases the DNA fragment from pERT87-15 region was amplified. This fragment includes a polymorphous site in BamHI region of recognition. DNA analyses of the families members have been made and the genetical risk has been calculated by the Bayes method. The prognoses for both fetuses are good.