Top Abstract Purchase Related
Home
>
Node
>
Subnode

Thromboxane responsiveness of dog platelets is inherited as an autosomal recessive trait

Johnson, G.J.; Leis, L.A.; King, R.A.

Thrombosis and Haemostasis 65(5): 578-580

1991

ISSN/ISBN: 0340-6245
PMID: 1871719
Document Number: 375538
Most mongrel dogs have platelets that form thromboxane A2 (TXA2) from exogenous arachidonate, but they fail to aggregate or secrete in response to it. In contrast to these TXA2 insensitive (TXA2-) platelets, some dogs have TXA2 sensitive (TXA2+) platelets that aggregate and secrete when stirred with arachidonate. To evaluate the possible genetic basis for this difference, we carried out seven matings of mongrel dogs that yielded 48 viable offspring. Four matings of dogs with TXA2- platelets (presumed genotype TT) including 2 back-crosses, produced 32 pups with TXA2- (TT) platelets and 0 pups with TXA2+ platelets. A cross between a male with TXA2+ platelets (presumed genotype tt) and a female with TXA2+ (tt) platelets yielded 9 offspring with TXA2+ (tt) platelets and 0 with TXA2- platelets. Crossing a male presumed homozygous (TT) for TXA2- platelets with a female with TXA2+ (tt) platelets produced 2 pups with TXA2- (Tt) platelets and 0 pups with TXA2+ (tt) platelets. The same female with TXA2+ platelets crossed with a male presumed to be heterozygous (Tt) for TXA2- platelets yielded 2 pups with TXA2+ (tt) platelets and 3 pups with TXA2- (Tt) platelets. Segregation analysis of these data supports the hypothesis that the ability of dog platelets to aggregate and secrete in response to TXA2 is inherited as an autosomal recessive trait.

Document emailed within 1 workday
Secure & encrypted payments

Ensink, R.J.; Brunner, H.G.; Cremers, C.W. 1997: A new type of maxillofacial dysostosis, inherited as an X-linked or autosomal recessive trait Genetic Counseling 8(4): 285-290
Kinnon, C.; Jones, A. 1997: Genetics of inherited immunodeficiencies II: autosomal recessive disorders British Journal of Hospital Medicine 57(9): 424-426
Knoblauch, H.; Urban, M.; Tinschert, S. 1999: Autosomal recessive versus autosomal dominant inheritance in Larsen syndrome: report of two affected sisters Genetic Counseling 10(3): 315-320
Basevich, V.V.; Mevkh, A.T.; Varfolomeev, S.D. 1984: Kinetic mechanisms of enzyme activity of the thromboxane synthetase system. Thromboxane synthetase of human platelets Biokhimiia 49(9): 1538-1545
Finlay, A.Y. 1988: Major autosomal recessive ichthyoses Seminars in Dermatology 7(1): 26-36
Alvarez-Arratia, M.C.; Muñoz, A.; Martínez Camacho, S.; Buendía Hernández, A.; Attie, F.; Fragoso, R.; García Cruz, D.; Cantú, J.M. 1992: Recessive autosomal inheritance in Marfan syndrome Archivos del Instituto de Cardiologia de Mexico 62(4): 379-382
Frijns, C.J.; Wouda, E.J.; Linssen, W.H.; Snijders, C.J. 1994: 2 patients with autosomal recessive generalized myotonia Nederlands Tijdschrift Voor Geneeskunde 138(14): 726-728
Alonso, R.A.; Hernández, A.; Díaz, P.; Cantú, J.M. 1982: An autosomal recessive form of hemimelia in dogs Veterinary Record 110(6): 128-129
Danks, D.M.; Mayne, V.; Kozlowski, K. 1974: A precocious, autosomal recessive type of osteodysplasty Birth Defects Original Article Series 10(12): 124-127
Temtamy, S.A.; Meligy, R.E.; Osman, N.M.; Meguid, M.S.; Salem, S. 1974: A "new" bone dysplasia with autosomal recessive inheritance Birth Defects Original Article Series 10(10): 165-170
Zara, F.; De Falco, F.A. 2005: Autosomal recessive benign myoclonic epilepsy of infancy Advances in Neurology 95: 139-145
Inose, M.; Higuchi, I. 2002: Autosomal recessive chronic progressive external ophthalmoplegia Nihon Rinsho. Japanese Journal of Clinical Medicine 60(Suppl 4): 455-457
Best, R.G.; Mathis, J.N.; Shah, K.; Golden, R. 1994: Cystic fibrosis (CF) is an autosomal recessive genetic disease Journal of the South Carolina Medical Association 90(2): 78-79
Cantú, J.M.; Hernández, A.; Ramírez, J.; Bernal, M.; Rubio, G.; Urrusti, J.; Franco-Vázquez, S. 1975: Lethal faciocardiomelic dysplasia- a new autosomal recessive disorder Birth Defects Original Article Series 11(5): 91-98
Matsumura, K.; Shimizu, T. 1995: Severe childhood autosomal recessive muscular dystrophy Rinsho Shinkeigaku 35(12): 1422-1424
Bösze, P.; Czeizel, E.; Kiss, P.; Lászlo, J.; Papp, Z.; Sebök, J.; Tóth, A.; Tóth, Z. 1982: Recessive-inherited hydrocephalus (prenatal diagnostic and therapeutic considerations) Orvosi Hetilap 123(12): 723-729
Lisker, R.; Mutchinick, O.; Reyes, M.E.; Santos, M.A.; Flores, T.; García Ramos, G. 1984: Autosomal recessive heredity in a Mexican family with torsion dystonia Revista de Investigacion Clinica; Organo del Hospital de Enfermedades de la Nutricion 36(3): 265-268
Yamada, T.; Machi, M.; Kobayashi, T.; Goto, I.; Kuroiwa, Y. 1987: A case of autosomal recessive myotonia congenita: histochemical study Rinsho Shinkeigaku 27(5): 642-645
De Bleecker, J.; De Reuck, J.; Martin, J.J.; Ceuterick, C.; Carton, D.; Leroy, J. 1990: Autosomal recessive inheritance of polymicrogyria and dermatomyositis with paracrystalline inclusions Clinical Neuropathology 9(6): 299-304
Stevanović, R.; Glumac, S.; Trifunović, J.; Medjo, B.; Nastasović, T.; Marković-Lipkovski, J. 2009: Autosomal recessive polycystic kidney disease: case report Srpski Arhiv Za Celokupno Lekarstvo 137(5-6): 288-291