Multicentric clinical trial of a combination of 35 micrograms of ethinylestradiol and 2 mg of cyproterone acetate

Audebert, A.; Emperaire, J.C.; Gauthier, A.; Hallonet, P.; Hedon, B.; Lopes, P.; Quereux, C.; Roulier, R.; Audebert, A; Emperaire, J.C; Gauthier, A; Hallonet, P; Hedon, B; Lopes, P; Quereux, C; Roulier, R

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Multicentric clinical trial of a combination of 35 micrograms of ethinylestradiol and 2 mg of cyproterone acetate

Audebert, A.; Emperaire, J.C.; Gauthier, A.; Hallonet, P.; Hedon, B.; Lopes, P.; Quereux, C.; Roulier, R.

Revue Francaise de Gynecologie et d'Obstetrique 86(11): 697-699

1991

ISSN/ISBN: 0035-290X

PMID: 1838208

Document Number: 375420

The authors report the results of an open multicentric study of 136 women treated by a combination of 35 micrograms ethinylestradiol and 2 mg cyproterone acetate for cutaneous manifestation of hyperandrogenism. No pregnancy occurred during the treatment of 12 months. Comparison between the last treated and non treated cycle showed a significant difference (p less than 0.001) in the severity of acne lesions regardless of their sites. General and gynaecological tolerance were excellent.