Tissue glycolytic potentials of penaeid prawn, Metapenaeus monoceros during methylparathion, carbaryl and aldrin exposure
Reddy, M.S.; Rao, K.V.
Biochemistry International 23(2): 367-375
1991
ISSN/ISBN: 0158-5231 PMID: 1830481 Document Number: 375259
Changes in midgut gland and muscle tissue glycolytic potentials of M. monoceros following exposure to methylparathion [parathion-methyl], carbaryl and aldrin were studied. A decrease in total carbohydrates, glycogen and pyruvic acid, and an increase in lactic acid levels were observed. An increase in phosphorylase 'a' and aldehyde-lyase activity levels suggested increased formation of trioses during selected insecticide toxicity. A decrease in lactate dehydrogenase activity and an increase in lactic acid level were indicative of reduced mobilization of pyruvate into the citric acid cycle. During selected insecticide exposure, the prawn tissues adopted certain regulatory pathways resulting in enhanced glycolysis and a shift of metabolic emphasis from aerobiosis to anaerobiosis. All the above changes were more pronounced in the midgut gland than in muscle tissue. The per cent decrease/increase in activity was of the order aldrin > carbaryl > parathion-methyl. Therefore, these insecticides appeared to be neurotoxic, leading to disturbances in the prawn's carbohydrate catabolism.