The use of electron microscopy for diagnosing spongiform encephalopathies
Poleshchuk, N.N.; Kapitulets, S.P.; Il'kevich, I.G.; Kvacheva, Z.B.
Laboratornoe Delo 4: 42-44
1991
ISSN/ISBN: 0023-6748 PMID: 1715430 Document Number: 375100
The authors suggest an unsophisticated approach to laboratory diagnosis of spongiform encephalopathies induced by unconventional prion viruses, consisting in electron microscopic detection of abnormal helical Scrapie-associated fibrils. These fibrils are detectable in human and animal brain tissue samples and in cell cultures.
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