Structure of the neointima after balloon catheter injury of the rabbit aorta in the context of hypercholesterolemia: analysis of endothelial influence on lipid accumulation
Rekhter, M.D.; Andrianova, I.V.; Ragimov, S.E.; Andreeva, E.R.; Mironov, A.A.; Tararak, E.M.; Orekhov, A.N.
Arkhiv Patologii 53(2): 18-22
1991
ISSN/ISBN: 0004-1955 PMID: 2069521 Document Number: 374706
Balloon catheter de-endothelialization of abdominal aorta of cholesterol-fed rabbits was performed. As a result, partly endothelialized neointima was formed, consisting of smooth muscle cells and macrophages. Neutral lipids stored more intensely in non-endothelialized part of neointima. Preferential intracellular lipid accumulation in this area was observed while predominantly extracellular lipid accumulation was found in endothelium-covered part of neointima. It is supposed that endothelium inhibits intracellular lipid accumulation and at the same time stimulates an extracellular one, but as a whole it reduces the density of lipid inclusions in neointima.