Ingestion of diethylstilbestrol during pregnancy. its responsibility in the testicular feminization syndrome
Chryssicopoulos, A.; Kondi-Parhitis, A.; Kairi, D.; Vasiliadis, T.; Maragoudakis, A.
Presse Medicale 19(30): 1397-1400
1990
ISSN/ISBN: 0755-4982 PMID: 2146621 Document Number: 374222
We report the cases of two women who had testicular feminization with remnants of Müllerian ducts and whose mothers had received diethylstilbestrol (DES) during the first trimester of pregnancy. At laparotomy, masses were removed which had the microscopic appearances of testes and Fallopian tubes, and were confirmed as such at histology. There were three possible explanations for these genetic abnormalities: deficient antimüllerian hormone (AMH) secretion (or lack of sensitivity of Müllerian ducts to AMH); early testicular descent with regression of Müllerian ducts beyond the efficacy margin of AMH; exposure to DES in utero during the first trimester of pregnancy. In these two women, the most likely explanation seems to be the last one.