Hepatic eosinophilopoiesis from multipotent hemopoietic stem cells in Toxocara canis-infected mice
Maruyama, H.; Higa, A.; Asami, M.; Owhashi, M.; Nawa, Y.
Experimental Hematology 19(2): 77-80
1991
ISSN/ISBN: 0301-472X PMID: 1991497 Document Number: 373829
Extramedullary hemopoiesis, recognized as hemopoietic foci, increased in the livers of Toxocara canis-infected mice. At the peak of the response (day-13 after infection), the majority of hepatic hemopoietic foci were of the eosinophil lineage. Hepatic nonparenchymal cells prepared from T. canis-infected mice on day 13 contained large numbers of hemopoietic stem cells, more than half of which were cycling. When W/Wv mice, which are genetically deficient in multipotent hemopoietic stem cells, were infected with T. canis, hepatic hemopoietic foci were rare throughout the course of infection. This impaired response of W/Wv mice was restored by bone marrow grafting from normal +/+ littermates. These results indicate that, in response to the increased demand, eosinophils are generated in the liver by the differentiation from multipotent stem cells, not only from the committed precursors.