Study of viral replication in HbsAg positive chronic hepatitis
Tomás Gilabert, J.; Galán Navarro, M.I.; Caballero Morales, T.; Maroto Vela, M.C.; Ruiz Extremera, A.; Salmerón Escobar, F.J.
Revista Clinica Espanola 188(4): 174-177
1991
ISSN/ISBN: 0014-2565 PMID: 1784740 Document Number: 373794
Viral replication seric markers (VRSM), (BeHAg, BcHAg, and DNA-VHB) and the hepatic tissue BcHAg of thirty four patients suffering from chronic hepatopathies (6 PCH, 18 ACH, and 10 cirrhosis) were investigated. The greatest incidence of RVSM was observed in PCH. The combined study using all the markers demonstrated a positive correlation: DNA-VHB and BeHAg (p less than 0,001); DNA-VHB and BcHAg (p less than 0,001); BeHAg and BcHAg (p less than 0,001). The same result was obtained when comparing BcHAg (n) with the rest of RVSM: DNA-VHB (p less than 0,001), BeHAg (p less than 0,001) and seric BcHAg (p less than 0,01). Patients with a most intense histologic activity according to the Knodell index, presented a higher ratio of positive nuclei for BcHAg. The conclusion is that there is a good correlation amongst replication markers, specially hepatic BcHAg and DNA-VHB.