Differences in the responses of the canine basilar and dorsal pedal artery to phenylephrine, clonidine and serotonin
Sotníková, R.; Gibala, P.
Methods and Findings in Experimental and Clinical Pharmacology 13(6): 427-433
1991
ISSN/ISBN: 0379-0355 PMID: 1652671 Document Number: 373682
The effects of phenylephrine, clonidine and serotonin were studied on isolated preparations of the canine basilar and dorsal pedal artery. Differences were mainly observed in the responses of the two types of arterial preparations to clonidine and phenylephrine. While in the dorsal pedal artery, .alpha.1- and .alpha.2-receptors were involved in the response to .alpha.-agonists, in the basilar artery contractions induced by .alpha.2-receptor stimulation prevailed. Moreover, in the latter artery the contractile responses induced by each of the agonists used were more dependent on the presence of extracellular calcium than those in the dorsal pedal artery.