Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effects of intratracheal instillation of fenvalerate on the ultrastructures of pulmonary alveolar macrophages in rat

Wang, X.R.; Zhai, W.L.

Zhongguo Yao Li Xue Bao 12(5): 415-420

1991

ISSN/ISBN: 0253-9756
PMID: 1819896
Document Number: 372545
On 1 d after instillation of fenvalerate (Fen) 0.19, 0.93, 4.66, and 23.3 mg .cntdot. kg-1, and on 30 min, 4 h, 1 d, 4 d, and 7 d after instillation of Fen 4.66 mg .cntdot. kg-1 by a single intratracheal instillation, respectively, the ultrastructural changes in rat pulmonary alveolar macrophages (PAM) were observed, and the toxicity indices (TI) were calculated. It was found that the ineffective dose of Fen was 0.19 mg .cntdot. kg-1, and the threshold dose was .gtoreq. 0.93 mg .cntdot. kg-1 as well as the serious intoxication dose .gtoreq. 4.66 mg .cntdot. kg-1. The results suggest that Fen is quickly toxic to rat lungs and quickly biodegraded in the lungs.

Document emailed within 1 workday
Secure & encrypted payments

Suntres, Z.E.; Hepworth, S.R.; Shek, P.N. 1993: Pulmonary uptake of liposome-associated alpha-tocopherol following intratracheal instillation in rats Journal of Pharmacy and Pharmacology 45(6): 514-520
Taganovich, A.D. 1991: Surfactant-inducted suppressive action on fibroblasts of pulmonary macrophages from rats with fibrosis after intratracheal administration of bleomycin Problemy Tuberkuleza 12: 46-49
Popenoe, D. 1979: Pulmonary effects of intratracheal cyclophosphamide Proceedings of the Western Pharmacology Society 22: 265-268
Barth, J.; Kreipe, H.; Radzun, H.J.; Petermann, W. 1990: Interleukin 1 secretion from alveolar macrophages in pulmonary sarcoidosis Pneumologie 44(Suppl 1): 215-216
Kalinina, M.V.; Gracheva, M.P. 1991: The NBT test of alveolar macrophages in patients with infiltrative pulmonary tuberculosis Problemy Tuberkuleza 9: 54-55
Erokhin, V.V.; Lepekha, L.N.; Nikolaeva, G.M. 1996: The morphofunctional heterogeneity of the alveolar macrophages in disseminated pulmonary tuberculosis Problemy Tuberkuleza 1: 51-56
Fetisov, V.V.; Litvinov, N.N.; Gasimova, Z.M. 1987: Ultrastructure of pulmonary alveolar macrophages in peroral exposure to nitrosodimethylamine Biulleten' Eksperimental'noi Biologii i Meditsiny 103(1): 114-117
Hengst, J.C.; Kan-Mitchell, J.; Kempf, R.A.; Strumpf, I.J.; Sharma, O.P.; Kortes, V.L.; Mitchell, M.S. 1985: Correlation between cytotoxic and suppressor activities of human pulmonary alveolar macrophages Cancer Research 45(1): 459-463
Blouin, A.; Kingma, I.; Boutet, M. 1994: An innovative technical approach for repetitive intratracheal instillation without anesthesia in small animals Laboratory Animal Science 44(3): 274-279
Reynolds, H.Y.; Thompson, R.E. 1973: Pulmonary host defenses. II. Interaction of respiratory antibodies with Pseudomonas aeruginosa and alveolar macrophages Journal of Immunology 111(2): 369-380
Sone, S.; Fidler, I.J. 1981: Activation of rat alveolar macrophages to the tumoricidal state in the presence of progressively growing pulmonary metastases Cancer Research 41(6): 2401-2406
Gerberick, G.F.; Jaffe, H.A.; Willoughby, J.B.; Willoughby, W.F. 1986: Relationships between pulmonary inflammation, plasma transudation, and oxygen metabolite secretion by alveolar macrophages Journal of Immunology 137(1): 114-121
Kang, K.Y.; Salvaggio, J. 1976: Effects of asbestos and beryllium compounds on the alveolar macrophages Medical Journal of Osaka University 27(1-2): 47-58
Trigo, E.; Liggitt, H.D.; Breeze, R.G.; Leid, R.W.; Silflow, R.M. 1984: Bovine pulmonary alveolar macrophages: antemortem recovery and in vitro evaluation of bacterial phagocytosis and killing American Journal of Veterinary Research 45(9): 1842-1847
Meng, Y.; Yu, C.-h.; Li, T.; Li, W.; Cai, S.-x.; Li, X. 2013: Expression and significance of Toll-like receptor-4 in rats lung established by passive smoking or associated with intratracheal instillation of lipopolysaccharide Zhonghua Yi Xue Za Zhi 93(28): 2230-2234
Sugimoto, M.; Ando, M.; Araki, S. 1984: Studies on lung defenses: effects of various inhalants on the function of alveolar macrophages Nihon Kyobu Shikkan Gakkai Zasshi 22(9): 757-761
Williams, R.A. 1995: Lipid-laden alveolar macrophages may indicate either aspiration pneumonia or sickle cell acute chest syndrome associated with pulmonary fat embolism Archives of Pathology and Laboratory Medicine 119(9): 772
Chen, J.; Ziboh, V.; Giri, S.N. 1997: Up-regulation of platelet-activating factor receptors in lung and alveolar macrophages in the bleomycin-hamster model of pulmonary fibrosis Journal of Pharmacology and Experimental Therapeutics 280(3): 1219-1227
Hasday, J.D.; Sitrin, R.G. 1987: Adenosine receptors on rabbit alveolar macrophages: binding characteristics and effects on cellular function Journal of Laboratory and Clinical Medicine 110(3): 264-273
Pradhan, A.; Waseem, M.; Dogra, S.; Khanna, A.Kumar.; Kaw, J.Lal. 2005: Alterations in bronchoalveolar lavage constituents, oxidant/antioxidant status, and lung histology following intratracheal instillation of respirable suspended particulate matter Journal of Environmental Pathology Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer 24(1): 19-32