Effects of intravenous and aerosolized arachidonic acid on alveolar epithelial permeability in rabbits
Stevenson, J.L.; Quan, S.F.; Witten, M.L.; Hall, J.N.; Roseberry, H.R.; McNeill, G.C.; Lemen, R.J.
Research Communications in Chemical Pathology and Pharmacology 72(1): 113-116
1991
ISSN/ISBN: 0034-5164 PMID: 1905059 Document Number: 372368
To determine whether arachidonic acid (AA) alters alveolar epithelial permeability, we studied the effect of both continuous intravenous and aerosolized AA on clearance of [99m]Tc-DTPA from lung to blood in rabbits. Although intravenous AA increased prostacyclin production and aerosolized AA decreased systemic blood pressure, neither continuous intravenous nor aerosolized AA augmented alveolar epithelial permeability.