Increased degradation of dermal collagen in diabetic rats
Rajkumar, L.; Srinivasan, N.; Balasubramanian, K.; Govindarajulu, P.
Indian Journal of Experimental Biology 29(11): 1081-1083
1991
ISSN/ISBN: 0019-5189 PMID: 1816088 Document Number: 371511
The effect of alloxan induced diabetes on the dermal collagen content of albino rats was studied in relation to few lysosomal enzymes. Diabetes decreased the dermal collagen content. The specific activities of the lysosomal enzymes studied in the diabetic rat skin were elevated. It has been established that lysosomal enzymes degrade the connective tissue components. Thus, it may be suggested that the increase in the lysosomal enzymes studied should have facilitated the decrease in dermal collagen content of diabetic rats by increasing the degradation of dermal collagen.