Study of chemically modified hemoglobin as an artificial oxygen carrier in the model of hemorrhagic shock in dogs
Selivanov, E.A.; Kochetygov, N.I.; Gerbut, K.A.; Azhigirova, M.A.; Viazova, E.P.; Zeĭnalov, A.M.; Bystrova, I.M.; Molokovskaia, E.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 112(8): 142-144
1991
ISSN/ISBN: 0365-9615 PMID: 1723902 Document Number: 370165
Hemodynamic and gas-transporting properties of the chemically modified hemoglobin solution have been studied on the model of hemorrhagic shock in dog. It has been shown that the polymerized hemoglobin solution exerts the hemodynamic action just as the plasmasubstitute "polyglucin" does. However, in contrast to the latter, polyhemoglobin circulating in the vascular bed for a prolonged period of time increases the blood oxygen capacity and oxygen delivery to tissues with the resultant increase in body total oxygen taking-up.