Changes in collagen biosynthesis in patients with hip joint replacement surgery and reoperation
Becvár, R.; Myllylä, R.; Krbec, M.; Cech, O.; Adam, M.
Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca 58(3): 178-184
1991
ISSN/ISBN: 0001-5415 PMID: 1832808 Document Number: 369861
The authors investigated the intensity of collagen synthesis in patients subjected to operation or re-operation of a total endoprosthesis of the hip joint. The patients suffered from osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. The authors assessed the activity of collagen glucosyl transferase (S-GGT) and the concentration of the N-terminal propeptide procollagen type III by two methods (S-Pro III-N-P and S-Fab) in serum before and after operation. A significant rise of S-GGT and S-Fab, as compared with controls, occurred only after operation while S-Pro III-N-P was elevated already before operation. S-GGT did not differ before and after operation, while N-propeptide concentration rose when either method was used.