The metabolic index of nocturnal hypoxia in patients after lung resection and thoracoplasty
Kubota, O.; Nishimura, K.; Inoue, Y.; Akutsu, H.; Mizuno, H.
Nihon Kyobu Shikkan Gakkai Zasshi 29(7): 844-848
1991
ISSN/ISBN: 0301-1542 PMID: 1920980 Document Number: 369280
The authors measured urinary uric acid (UA) and creatinine (CR), serum lactate, and CoQ10 prior to retiring at night and on awakening in the morning in 127 patients (PG) after lung resection and thoracoplasty which were done more than 20 years age for treatment of tuberculosis and in 20 controls (NC), .DELTA. UA:CR, .DELTA. lactate, and .DELTA. CoQ10 were calculated respectively as the overnight changes in urinary UA:CR and in serum lactate and CoQ10. .DELTA. UA:CR increased in PG (4.0 .+-. 43.6%), whereas it decreased in NC (-22.3 .+-. 17.7%) (mean .+-. SD) (p < 0.05). Nocturnal hypoxemia suggested from positive balance of .DELTA. UA:CR was seen in 37% of PG, but in only 10% of NC. .DELTA. UA:CR showed no relationship with .DELTA. lactate and .DELTA. CoQ10 and also did not correlate with the nadir of arterial oxygen saturation. PG were divided into PG with a positive balance of .DELTA. UA:CR (PG-P) and with a negative balance of .DELTA. UA:CR (PG-N). The %VC and PaO2 in the PG-P group were lower and PaCO2 was higher than in PG-N, although the difference did not acheive statistical significance.