Beta-receptor decrease in bronchial asthma
Oehling, A.; Sanz, M.L.; Gamboa, P.M.
Allergie et Immunologie 23(7): 285-288
1991
ISSN/ISBN: 0397-9148 PMID: 1660275 Document Number: 369152
Sinesterases that intervene in cAMP and oGMP equilibrium in the cytoplasm of mast cells are activated by the adrenergic system through beta-receptors. A study was made on 96 atopic patients with mono sensitization to Dermatophagoides pteronissinus, in 3 groups. Radioligands were used to quantitate the number of beta receptors. In the control group mean no/cell was 541, bronchial symptomatic patients had 327 and nasal symptomatics 348. Asymptomatic patients were similar to controls. The results were similar with pollen-sensitive patients. Beta receptor decrease is a consequence of clinical allergy in atopic patients and is secondary to the immunological events that follow antigen-antibody reactions and cell membrane changes.