Serum copper levels in users of multiload intra-uterine contraceptive devices
Arowojolu, A.O.; Otolorin, E.O.; Ladipo, O.A.
African Journal of Medicine and Medical Sciences 18(4): 295-299
1989
ISSN/ISBN: 0309-3913 PMID: 2558561 Document Number: 368960
The systemic absorption of copper incorporated into multiload IUDs as indicated by serum copper levels in users of such devices was assessed in a prospective, longitudinal study. 110 healthy Nigerian women using either a multiload copper 250 (MLCU 250) or the MLCU 375 participated in this study. Their serum copper levels were estimated serially during 12 months of continuous use. The mean (+or- s.e.m.) preinsertion serum copper levels in those subjects using the MLCU 250 were 17.0 +or- 3 mcmol/l and 16.7 +or- 0.5 mcmol/l in those using the MLCU 375. These levels were lower than those levels reported in Americans (22.2 mcmol/l) and in Germans (20.2 mcmol/l), although they were similar to those in Indians (17.0 mcmol/l). There was no significant difference in the mean serum copper levels estimated before and after 1 month of continuous use of the device. Serial estimations of the serum copper levels in users showed that there was no alteration in these levels after a period of 12 months of continuous IUD use. The authors conclude that the copper incorporated into multiload IUDs appears not to influence the concentration of serum copper in users. (author's modified)