Disordered lymphoid regulation of hematopoiesis in iron-deficiency anemia
Bazarnyĭ, V.V.; Iastrebov, A.P.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 3: 34-36
1991
ISSN/ISBN: 0031-2991 PMID: 1923612 Document Number: 368680
Iron-deficiency anemia (IDA) in rats is attended by secondary cellular immunodeficiency. The authors studied the importance of lymphocyte dysfunction in the pathogenesis of hematological disorders in rats with IDA. Transplantation of lymphocytes from intact donors subjected to hypoxia to syngeneic recipients led to stimulation of erythropoiesis in them. The effect of "iron deficiency' cells was less manifest. It was established that the hematological disorders in IDA are lymphocyte-determined. This was also demonstrated in experiments on rats with IDA and changed functional condition of the lymphoid tissue.