Hormonal contraceptives, human papillomaviruses and cervical cancer; some observations from a colposcopy clinic
Chang, A.R.
Australian and New Zealand Journal of Obstetrics and Gynaecology 29(3 Part 2): 329-331
1989
ISSN/ISBN: 0004-8666 PMID: 2559710 DOI: 10.1111/j.1479-828x.1989.tb01756.xDocument Number: 368231
Case records of 434 women, all those referred from Otago Province, New Zealand, to the culdoscopy clinic from 1982-1985, for abnormal cervical smears, were examined with respect to age, method of contraception, smoking and results correlated with incidence of human papilloma virus (HPV) infection. 71% of the women had CIN3 lesions (carcinoma in situ stage III) and of these 71 had HPV also. 63.3% of the users of hormone contraception (pills or injections) had both CIN3 and HPV, while 43.8% had only CIN3 (p0.004). There were no significant differences in proportion of women smokers. Although younger women tended to use hormonal contraception, there were no significant differences between the CIN3 + HPV and the CIN3 only groups with respect to age. Since even higher prevalence of HPV is found among women with precancerous lesions when the DNA probing method is used, it is vital that more thorough studies be done concerning the link between oral and other hormonal contraception and cervical neoplasms, especially considering the enhanced considering the enhanced role they currently play personally as well as globally.