Insulin-like growth factor i (IGF-I) and growth in children undergoing hemodialysis or after successful renal transplantation
Jasper, H.G.; Ferraris, J.R.
Medicina 51(2): 127-132
1991
ISSN/ISBN: 0025-7680 PMID: 1820498 Document Number: 367836
To analyze the relationship between IGF-I and growth in children with chronic renal failure, we studied 7 patients undergoing hemodialysis and 7 patients after successful renal transplantation. IGF-I was measured by acid chromatography using ODS silica columns. Hemodialyzed patients grew poorly (mean 1.5 cm/y), and although transplanted patients did significantly better (mean 3.3 cm/y), 4 out of 7 did not reach normal height velocity. IGF-I levels in transplanted patients (39.2 +/- 13.6 nM/l) were significantly higher than in hemodialyzed patients (13.4 +/- 3.0 before; 17.0 +/- 5.4, after dialysis, nM/l). Nevertheless, all individual values in both groups fell within normal limits. The mean logarithmic deviation of IGF-I values of hemodialyzed patients was not significantly different from normal. The logarithmic deviation of transplanted patients was significantly higher than normal, indicating a true, albeit slight, increase in the levels of this growth factor No significant correlation was found between IGF-I and growth velocity. Serum IGF-I levels in these children do not help to explain their growth failure.