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Effect of propranolol on electrophysiologic features of the heart in patients with hyperthyroidism

Gasińska, T.; Prochaczek, F.; Izbicka, M.

Endokrynologia Polska 42(4): 533-542

1991

ISSN/ISBN: 0423-104X
PMID: 1364504
Document Number: 367782
The effect of increasing doses of intravenously administered propranolol on electrophysiological features of heart was studied in 17 patients with untreated hyperthyroidism by using the transesophageal stimulation method. A positive and dose-dependent effect of propranolol on the studied parameters was found with the normalization of the majority of disturbances taking place after the administration of 6 mg of propranolol. This dose was safe and well tolerated by the patients. The sensitivity of the auriculo-ventricular junction to propranolol was less pronounced during the stimulated rhythm than during the sinus rhythm.

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