Immunosuppressive effect of cyclosporin a incapsulated into liposomes
Arnoux, R.; Dufourcq, J.; Smeesters, C.; Lalanne, J.; Deminière, C.; Penin, E.; Clerc, M.; Poteaux, L.; Dartigues, J.F.; Michel, A.
Chirurgie; Memoires de l'Academie de Chirurgie 116(8-9): 699-703
1990
ISSN/ISBN: 0001-4001 PMID: 2129987 Document Number: 367360
A preparation of cyclosporine A (CsA) in small liposomes (300 nm) was tested in a rat model of heterotopic cardiac allograft. At a daily dose of 1,5 mg/kg during 14 days, the graft survival rate was 30.4 +/- 2.8 days with a liposome-CsA solution versus 16 +/- 2.3 days with a Cremophore-CsA solution (p less than 0.01). Animals treated with the liposome-CsA preparation exhibited less weight loss than animals treated with cremophore-CsA solution (p less than 0.01). It is likely that the up-take of CsA by macrophages, when incapsulated into liposomes is dramatically enhanced; these cells have been pointed out at targets for IL2 inhibition by CsA.