Myxomatous stromal changes in bone marrow following chemotherapy of acute leukemia--immunohistochemical characteristics of matrix components

Nagasaka, T.; Nakashima, N.; Sumiyoshi, N.; Toda, M.; Nishio, K.; Kato, Y.; Takeuchi, J.

Rinsho Byori. Japanese Journal of Clinical Pathology 38(12): 1358-1362


ISSN/ISBN: 0047-1860
PMID: 2082034
Document Number: 366867
Although fibrosis and gelatinous transformation of bone marrow stroma are well known, there have been few histopathological descriptions in the literature. We studied 16 cases of acute leukemia, and describe the myxomatous changes of bone marrow stroma observed at 2 or 3 weeks following chemotherapy. We analyzed the extracellular matrix components immunohistochemically, using monoclonal or polyclonal antibodies raised against collagens, proteoglycans (PG), fibronectin and laminin. We found that the major components of the myxomatous matrix were chondroitin 6-sulfate PG and large PG. The stainability resembles that of extracellular matrix components in long-term bone marrow culture. We suppose that the myxomatous matrix provides favorable conditions for hematopoiesis, because hematopoietic cells proliferate and differentiate as soon as such stromal changes occur.

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