Effect of N-acetylneuraminic acid on respiratory tract secretion and inflammation in the bronchitic rabbit

Miyata, T.; Ishii, T.; Sugiyama, N.; Okano, Y.; Nishi, N.; Takahama, K.; Ogasawara, S.; Oda, Y.; Yokoyama, K.; Murata, Y.

Archives Internationales de Pharmacodynamie et de Therapie 304: 277-289


ISSN/ISBN: 0003-9780
PMID: 2241415
Document Number: 366628
Long-term exposure of rabbits to SO2 gas caused the following changes in the respiratory tract system: decreases in the respiratory rate and pO2 blood level; an increase in the viscosity of sputum associated with increases in protein, unsaturated phosphatidylethanolamine and sphingomyelin; subacute rhinitis, tracheitis and multiple bronchopneumonia. Pretreatment with repeated administrations (inhalations) of N-acetylneuraminic acid remarkably prevented these inflammatory changes. The significance of this finding is discussed.

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