Nerve fiber regeneration in preformed tissue spaces

Dietzmann, K.; Künnemann, J.; Vitzthum, H.E.

Zentralblatt für Allgemeine Pathologie U. Pathologische Anatomie 136(6): 579-585


ISSN/ISBN: 0044-4030
PMID: 2281724
Document Number: 366493
Described in this paper is a new artificial chamber model to enable in vivo investigation of nerve fiber regeneration. Transection of the sciatic nerve of a rat was followed by analysis of axonal regeneration and revascularisation in the tissue chamber. Vascularisation of the endoneurium via the newly formed epineurium and perineurium was almost physiological in the cavity formed. The latter was found to be suitable for application of drugs and neurotrophic substances.

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