A case of a gastric cancer patient with high serum pepsinogen levels at relapse

Kimura, Y.; Fujii, T.; Miyagawa, N.; Tanada, S.; Hamamoto, K.; Kimura, S.

Gan no Rinsho. Japan Journal of Cancer Clinics 36(8): 945-948


ISSN/ISBN: 0021-4949
PMID: 2366328
Document Number: 366467
A rare case of a 68-year-old female cancer patient with an extremely high serum level of pepsinogens (PG) at relapse is presented. She had stage 3 Borrmann 3 type gastric cancer which was a poorly differentiated adenocarcinoma. Her postoperative serum PG levels had been within normal limits (23.0 ng/ml for PG-I and 3.2 ng/ml for PG-II), but at the time of the peritoneal relapse they were 5,630 ng/ml and 3,380 ng/ml, respectively. After was chemotherapy initiated, her serum PG levels decreased in parallel with an improvement of her clinical status. Immunohistochemical examination with monoclonal antibodies revealed PG-I and PG-II production in the primary and the metastatic lesions.

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