Protein C deficiency in a black South African family. A case report
Chetty, N.; Caplan, B.A.; Reavis, S.C.; Dukes, I.A.; Patel, M.
South African Medical Journal 77(4): 208-209
1990
ISSN/ISBN: 0256-9574 PMID: 2300856 Document Number: 365296
Protein C is a vitamin K-dependent anticoagulant that functions by inhibiting the activity of factors Va and VIIIa. An inherited deficiency of this protein may enhance the risk of thrombosis. The first kindred with levels of protein C that averaged 50% of normal in association with recurrent thrombotic events were described in 1981. A black South African family with an inherited deficiency of this protein is reported.