Immunoreactive corticotropin-releasing hormone levels in brain regions of genetically obese Zucker rats
Nakaishi, S.; Nakai, Y.; Fukata, J.; Naito, Y.; Usui, T.; Imura, H.
International Journal of Obesity 14(11): 951-955
1990
ISSN/ISBN: 0307-0565 PMID: 2276856 Document Number: 364787
Concentrations of immunoreactive corticotropin-releasing hormone (ir-CRH) were estimated in discrete brain regions and pituitary of obese Zucker rats and their lean littermates. Ir-CRH concentrations were lower in the hypothalamus and neurointermediate pituitary but higher in the striatum and cerebellum of obese Zucker rats than those of lean littermates. Results suggest some abnormalities in the CRH regulating system in obese Zucker rats.