Alcoholism and depression: a placebo controlled study with viloxazine
Altamura, A.C.; Mauri, M.C.; Girardi, T.; Panetta, B.
International Journal of Clinical Pharmacology Research 10(5): 293-298
1990
ISSN/ISBN: 0251-1649 PMID: 2079386 Document Number: 364492
Depressive disorders are frequently associated with alcohol abuse. Though many studies have been carried out to clarify the role of antidepressant drugs in the management of alcoholic patients, the data are controversial. The present placebo-controlled study was planned to assess the antidepressant and attenuating drinking-behaviour efficacy of viloxazine (400 mg per os daily) versus a placebo in 30 dysthymic patients affected by alcohol dependence. The results significantly favour viloxazine treatment in alleviating depression and in reducing alcohol abuse. All patients showed baseline haematochemical evidence of liver dysfunction that did not change significantly during the treatment.