The distribution of S-100 protein in articular cartilage from osteoarthritic joints
Chen, F.; Kerner, M.B.; Dorfman, H.D.; Hamerman, D.
Journal of Rheumatology 17(12): 1676-1681
1990
ISSN/ISBN: 0315-162X PMID: 2084243 Document Number: 364094
The distribution and localization of S-100 protein was compared with safranin-O staining and H and E morphology in relatively unaffected, degenerative, and osteophytic regions of human articular cartilage from 26 joints obtained at the time of total joint replacement for osteoarthritis. S-100 protein immunoreactivity in osteophyte cartilage was more intense than in unaffected regions and comparable to the staining intensity found in metaplastic cartilage tufts in degenerating cartilage. Immunoreactivity for S-100 protein appeared more prominent in the deep layers of osteophyte cartilage adjacent to areas of matrix calcification.