Diabetes, malnutrition and growth retardation

Ketelslegers, J.M.; Maes, M.; Maiter, D.; Thissen, J.P.; Triest, S.; Underwood, L.E.; Lambert, A.E.; Ketelslegers, J.M; Maes, M; Maiter, D; Thissen, J.P; Triest, S; Underwood, L.E; Lambert, A.E

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Diabetes, malnutrition and growth retardation

Ketelslegers, J.M.; Maes, M.; Maiter, D.; Thissen, J.P.; Triest, S.; Underwood, L.E.; Lambert, A.E.

Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 145(1-2) 132-141; Discussion: 141-143

1990

ISSN/ISBN: 0377-8231

PMID: 2116933

Document Number: 363930

We investigated the cellular mechanisms responsible for growth hormone (GH) resistance in diabetes and malnutrition in the rat. In insulin-dependent diabetes, a post-receptor defect participates in GH resistance. During fasting, there is a loss of liver GH binding sites. Dietary protein restriction causes a post-receptor defect. This defect can be attributed to the combined effects of decreased liver IGF-I mRNA content and impaired message translation.