Senescence grading system in mice
Hosokawa, M.
Rinsho Byori. Japanese Journal of Clinical Pathology 38(5): 539-542
1990
ISSN/ISBN: 0047-1860 PMID: 2381080 Document Number: 363647
A grading system was devised to evaluate the degree of senescence in accelerated senescence prone (SAM-P) and resistant (SAM-R) mice, using 11 items considered to be associated with senescence. The items were graded from 0 to 4. For most items, the score and incidence began to increase from 4-6 month-old, continued to increase with age in both SAM-P and SAM-R and reached similar plateau levels at 12-16 months and 24 months, respectively. In both SAM-P/1 at 8 month-old and SAM-R/2 at 12 month-old, there was an inverse correlation between the total score and duration of survival after examination. Thus, the grading system is useful for evaluation of the degree of senescence of mice.